1 edition of Selected abstracts on prostaglandins and carcinogenesis found in the catalog.
Selected abstracts on prostaglandins and carcinogenesis
by U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Technical Information Service [distributor in Bethesda, Md, Springfield, Va
Written in English
|Statement||R.S. Bockman, consulting reviewer.|
|Contributions||Bockman, R. S., National Institutes of Health (U.S.), International Cancer Research Data Bank.|
|The Physical Object|
|Pagination||vii, 81 p. ;|
|Number of Pages||81|
This title is also available as an eBook. You can pay for Springer eBooks with Visa, Mastercard, American Express or Paypal. After the purchase you can directly. Abstract: Prostaglandin endoperoxide H synthase (PGHS) is a key enzyme for the synthesis of prostaglandins (PGs) which play important roles in inflammation and carcinogenesis. Because the extract from Psidium guajava psidium guajava Subject Category: Organism Names see more details is known to have a variety of beneficial effects on our body including the anti-inflammatory, antioxidative .
The bioactive lipid Prostaglandin E2 (PGE2) is involved in several steps of carcinogenesis in some of the most common cancers, e.g. colon cancer, lung cancer, prostate cancer and breast cancer. Carcinogenesis and Dietary Fat (Prostaglandins, Leukotrienes, and Cancer (6)): Medicine & Health Science Books @
Abstract Continuous use of nonsteroidal anti-inflammatory drugs (NSAIDs) lowers the relative risk of colorectal cancer in humans and decreases tumor yield in rodents treated with carcinogens. One well documented target for NSAIDs is prostaglandin endoperoxide synthase (cyclooxygenase) and two isoforms of this enzyme have been identified. Prostaglandins are endogenous mediators formed from arachidonic acid by cyclooxygenases and prostaglandin synthases during inflammatory processes. The five-membered ring can be dehydrated, and α,β-unsaturated cyclopentenone PGs (cyPGs) are generated. Recent studies have been focused on their potential pharmacological use against inflammation and cancer. However, .
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Print book: Government publication: EnglishView all editions and formats: Rating: (not yet rated) 0 with reviews - Be the first. Subjects: Prostaglandins -- Abstracts. Carcinogenesis -- Abstracts. Cell Transformation, Neoplastic. View all subjects; More like this: Similar Items.
Author(s): Bockman,R S; International Cancer Research Data Bank.; Cancer Information Dissemination and Analysis Center (CIDAC) for Carcinogenesis Information.
Title(s): Selected abstracts on prostaglandins and carcinogenesis/ R.S. Bockman, consulting reviewer. The inhibitory effect of 40 and 80% maximum tolerated dose (MTD) levels of piroxicam, ibuprofen, ketoprofen and glycyrrhetinic acid on colon carcinogenesis was investigated in male F rats.
The MTD levels of piroxicam, ibuprofen, ketoprofen and glycyrrhetinic acid as determined in male E rats were, and p.p.m. by: INCREASED amounts of prostaglandins, especially prostaglandin (PG) E2 (PGE2), have been detected in human cancer tissue as well as in cultured mouse fibrosarcoma cells1.
Elevated prostaglandin Cited by: Abstract. Prostaglandins (PGs) and their analogs endoperoxides are a large series of compounds which mainly enhanced cancer development and progression, acting as cocarcinogens or tumor promoters, and having profound effects on carcinogenesis.
Although PGs are ubiquitous tissue hormones exerting pleiotropic effects on cancer cells, their Cited by: Part of the Prostaglandins, Leukotrienes, and Cancer book series (PLAC, volume 2) Abstract This suspicion was first voiced by Rehn in (1) after he noticed three cases of bladder cancer among workers employed at an amine-derived dye factory in Germany.
It has been proposed that the promoting effect of a high-fat diet on carcinogenesis is the result of an accelerated formation of arachidonic acid and subsequently of prostaglandins. The ω-6 PUFA, particularly linoleic acid, gives rise to prostaglandins and leukotrienes of the 2-series via arachidonic acid, which can affect cell proliferation.
Abstract. There is considerable evidence that lipids, and specifically prostaglandins (pgs), can contribute to progressive tumor growth (1). Many studies provide evidence that lipids can contribute to early steps in carcinogenesis, in particular early promotional events. Chamomile treatment inhibited the release of LPS-induced prostaglandin E(2) in RAW macrophages.
This effect was found to be due to inhibition of COX-2 enzyme activity by chamomile. In addition, chamomile caused reduction in LPS-induced COX-2 mRNA and protein expression, without affecting COX-1 expression.
Abstract: Eicosanoids, which originate from polyunsaturated fatty acids (PUFAs), have a major impact on homeostasis maintenance as secondary signal transducers. Signal cascade, which includes reception, processing and signal transduction coming from the environment into the cell, determines the type of response evoked.
Prostaglandins and Medicine 5:Review REVIEW: PROSTAGLANDINS AND CANCER Rashida A. Karmali, Developmental Immunology, Cellular Engineering & Cancer Therapy, Memorial Sloan-Kettering Cancer Center, York Avenue, New York, New York (reprint requests to RAK) ABSTRACT This paper reviews work on the role of prostaglandins in cancer A.
PROSTAGLANDINS PROSTAGLANDINS AND CANCER: A REVIEW OF TUMOR INITIATION THROUGH TUMOR METASTASIS Kenneth V. Honnl,3,4, Richard S. Bockman5, ano Lawrence J.
Marnett2 Departments of Biological SciencesI, Chemistry2, Radiation Oncology3, and Radiology4, Wayne State University, Detroit Michigan Department of Calcium Metabolism5. Prostaglandin E 2 (PGE 2) is a bioactive lipid that mediates a wide range of physiological effects and plays a central role in inflammation and 2 is generated from arachidonic acid by the sequential actions of the cyclooxygenases (COXs) and terminal synthases (PGES).
Increased levels of COX-2, with a concomitant elevation of PGE 2, are often found in colorectal cancers (CRC. Terragno A, Rydzik R, Terragno NA. High performance liquid chromatography and UV detection for the separation and quantitation of prostaglandins.
Prostaglandins. Jan; 21 (1)– Reddy BS, Sugie S. Effect of different levels of omega-3 and omega-6 fatty acids on azoxymethane-induced colon carcinogenesis in F rats.
Prostaglandin H synthase-dependent mutagenic activation of heterocyclic aromatic amines of the IQ-type. Carcinogenesis. Apr; 8 (4)– Degen GH, Wong A, Eling TE, Barrett JC, McLachlan JA.
Involvement of prostaglandin synthetase in the peroxidative metabolism of diethylstilbestrol in Syrian hamster embryo fibroblast cell cultures.
Books. An illustration of two cells of a film strip. Video. An illustration of an audio speaker. Audio. An illustration of a " floppy disk. Software. An illustration of two photographs. Full text of "Carcinogenesis abstracts" See other formats.
Key mediators connecting inflammation and BE carcinogenesis include ROS, NFκB pathway activation, inflammatory cytokines, prostaglandins, and immune modulatory microRNAs . For instance, IL. COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus.
[Show full abstract] intensive research on prostaglandins, thromboxanes, leukotrienes, and other members of this family of lipid mediators, now summarized under the more general term.
Abstract. The effect of purified eicosapentaenoic acid (EPA, n-3 polyunsaturated fatty acid) on azoxymethane(AOM)-induced colon carcinogenesis, the alteration of fatty acid composition, and prostaglandin E 2 in colon tumors and normal colon mucosa were studied, in comparison to linoleic acid(n-6 polyunsaturated fatty acid).
The tumor incidence. Get this from a library! Selected abstracts on transplacental carcinogenesis. [Lucy M Anderson; Cancer Information Dissemination and Analysis Center (CIDAC) for Carcinogenesis Information.; International Cancer Research Data Bank.].The picture that comes out of this book describes a very complicated network of interactions between arachidonic acid metabolites and different as pects of the complex phenomenon "cancer".
Eicosanoids participate in carcinogenesis initiation and promotion, and their relationship with tumor promoters and growth factors is well established.Introduction.
Prostaglandins are important inflammatory mediators; PGE 2 is the predominant prostaglandin in colorectal neoplasia and affects colorectal carcinogenesis. Prostaglandins are metabolites of omega-6 and omega-3 polyunsaturated fatty acids; their biosynthesis is the primary target of nonsteroidal anti-inflammatory drugs (NSAIDs), which reduce colorectal neoplasia risk.